Endocrine Abstracts

Background: Transient Receptor Potential (TRP) channels are expressed in many epithelial cells and respond to mechanical or osmotic stress by initiating a number of calcium-dependent mechanisms. The human serum and glucocorticoid regulated kinase (hSGK) is one such calcium-dependent protein found in the kidney. Stimulated by cell shrinkage, this volume-regulated kinase stimulates sodium transport. Aberrant absorption of sodium has been implicated in the development of hyperten...

Introduction: Management of paediatric cortisol deficiency requires regular parent and child education and effective liaison with the emergency services. Best practice in the management of these patients is largely based upon local consensus. An annual steroid review service was introduced by the CNS team to provide education and improve parental understanding of the issues regarding cortisol deficiency in children. Emergency alert systems for the local children’s emergen...